Alfredo Chicken Zucchini Casserole

Featured in: Dinner Grin

This creamy casserole brings together succulent chicken, fresh zucchini, and a rich Alfredo sauce for a satisfying main dish. Baked until the cheese bubbles and turns golden, it’s filled with Italian-inspired flavors and comforting textures. Ideal for busy evenings, simply sauté vegetables, combine with cooked chicken and sauce, then top with mozzarella and Parmesan before baking. Finished with fresh parsley, each serving is low in carbs and offers a comforting meal the whole family can enjoy. Meal prep is simple, and you can add extra veggies for variety.

Updated on Thu, 23 Oct 2025 16:12:02 GMT
Golden baked Alfredo Chicken Zucchini Casserole, creamy, cheesy, and ready for dinner tonight. Save
Golden baked Alfredo Chicken Zucchini Casserole, creamy, cheesy, and ready for dinner tonight. | grinnosh.com

This Alfredo Chicken Zucchini Casserole is my absolute go-to when I want something that tastes indulgent but packs in plenty of veggies. It brings together juicy chicken, tender zucchini, and a luscious Alfredo creaminess, all baked until the top bubbles and browns. This is a real crowd-pleaser and an easy way to get the family to eat their greens. I love how it uses a handful of ingredients, transforms leftovers, and gives you that cozy, Italian-inspired comfort in under an hour.

I first whipped this up one chilly Sunday when all I had was leftover chicken and zucchini. Now my partner asks for it whenever we have a busy week ahead.

Ingredients

  • Cooked chicken breast cubed or shredded: Look for juicy chicken that is fully cooked but still moist
  • Fresh zucchini sliced into rounds: Choose firm zucchini with shiny skins for best texture
  • Onion finely chopped: Adds sweetness and flavor try yellow or sweet onions
  • Garlic minced: Use fresh cloves for richness and depth
  • Alfredo sauce homemade or store-bought for convenience: If you need gluten-free check the label
  • Sour cream: Full-fat gives the best creaminess
  • Mozzarella cheese shredded: Melts into gooey goodness look for low-moisture mozzarella
  • Parmesan cheese grated: Adds sharpness and a savory boost Go for fresh grated instead of canned
  • Dried Italian herbs: For classic flavor balance try to use fresh if you have them
  • Salt and black pepper: I recommend freshly cracked for brightness
  • Fresh parsley chopped: Adds color and a fresh note at the end

Instructions

Preheat and Prepare Dish:
Preheat your oven to 375 degrees Fahrenheit or 190 degrees Celsius. Lightly grease a 9 by 13 inch casserole dish with a bit of oil or butter to prevent sticking.
Sauté the Aromatics:
In a large skillet drizzle a small splash of olive oil and warm over medium heat. Add your finely chopped onion and cook for about three minutes stirring until translucent. Toss in the minced garlic and keep cooking for another minute until fragrant. This base will infuse the casserole with deep savory flavor.
Cook the Zucchini:
Add the sliced zucchini to the skillet with the onions and garlic. Stir occasionally and cook for five minutes until the zucchini is just becoming tender but still has vibrant green color. Avoid overcooking at this step so the zucchini keeps some bite in the casserole.
Combine Everything:
In a large mixing bowl add the cooked chicken the sautéed vegetables the Alfredo sauce the sour cream the Italian herbs salt and pepper. Mix everything gently with a spatula so the delicate zucchini holds its shape but the flavors blend.
Layer in Casserole:
Transfer the mixture into your prepared casserole dish. Use your spatula or the back of a spoon to spread it into an even layer from corner to corner for even baking.
Top with Cheese:
Sprinkle the shredded mozzarella over the surface and then follow with the grated Parmesan. These cheeses will melt and brown to a golden crust as the casserole bakes.
Bake to Perfection:
Place the casserole in your preheated oven and bake uncovered for twenty five to thirty minutes. Watch for bubbling edges and a golden cheesy top which signals it is done.
Let Rest and Garnish:
Remove the casserole from the oven and allow it to rest for about five minutes. This helps it set and makes it easier to serve. Finish with a sprinkle of chopped fresh parsley for color and freshness.
Close-up of a bubbling Alfredo Chicken Zucchini Casserole, cheesy and inviting from the oven. Save
Close-up of a bubbling Alfredo Chicken Zucchini Casserole, cheesy and inviting from the oven. | grinnosh.com

Parmesan is my favorite part of this dish Every time I sprinkle it over the casserole I remember my grandmother who said you can never have too much cheese She always insisted on freshly grated Parmesan and I now do the same for the very best flavor

Storage Tips

Store leftovers in an airtight container in the fridge for up to four days. To reheat cover and bake at 350 degrees Fahrenheit until warmed through or use the microwave for a quick lunch option. For longer storage wrap tightly and freeze for up to three months. Thaw overnight in the fridge before baking.

Ingredient Substitutions

Turkey makes a great substitute for chicken in this recipe and you can even use rotisserie chicken for quick prep. If you want to change up the veggies add sliced mushrooms or a handful of baby spinach to the sauté step. For a dairy-free option swap Alfredo and sour cream with plant-based alternatives and your favorite non-dairy cheeses.

Serving Suggestions

This casserole pairs perfectly with a crisp green salad dressed simply with olive oil and vinegar. If you are not gluten-free try serving it alongside buttery garlic bread. For a full meal I sometimes roast cherry tomatoes or steam broccoli as side dishes.

Cultural and Seasonal Background

Inspired by classic Italian flavors but adapted for busy American kitchens this casserole brings together comfort food with lighter seasonal fare. Summer zucchini adds fresh taste and balances the richness of Alfredo. This kind of recipe is a backyard barbecue favorite in late summer when zucchini is at its peak.

Seasonal Adaptations

Add fresh corn or cherry tomatoes in summer for extra sweetness and color In fall stir in cubes of roasted butternut squash for a cozy twist Opt for low fat dairy versions if you prefer a lighter casserole

Success Stories

Friends who thought they did not like zucchini always change their mind after one cheesy bite. My sister loves making this after hosting a dinner party because it is filling and impresses everyone while making her weeknights simpler.

Freezer Meal Conversion

Assemble the casserole right up to the cheese topping. Cover tightly and freeze unbaked. When ready to eat thaw overnight in the fridge and bake as directed adding an extra ten minutes if baking straight from the cold.

Delectable Alfredo Chicken Zucchini Casserole, perfect for a weeknight, with a creamy, golden crust. Save
Delectable Alfredo Chicken Zucchini Casserole, perfect for a weeknight, with a creamy, golden crust. | grinnosh.com

Leftover casserole makes an amazing next day lunch I will even eat it cold straight from the fridge if I am busy

Recipe FAQ

Can I make this gluten-free?

Absolutely. Use a certified gluten-free Alfredo sauce to keep the dish gluten-free. Always double-check labels for hidden gluten sources.

What can I use instead of chicken?

Cooked turkey is a tasty alternative, offering similar texture and flavor. You can also use rotisserie chicken for added convenience.

How do I add more vegetables?

Sliced mushrooms or baby spinach blend well with zucchini, enhancing nutrition and flavor. Simply sauté them with the onion and garlic.

Can I prepare this ahead of time?

Yes, assemble the casserole up to a day ahead and refrigerate. Bake when ready to serve for an easy dinner solution.

What tools do I need?

You'll need a 9x13-inch dish, large skillet, mixing bowl, chef’s knife, cutting board, and a wooden spoon or spatula for preparation.

Is it suitable for meal prep?

This dish stores well in the fridge, making it perfect for meal prep. Portion into containers for easy grab-and-go lunches or dinners.

Alfredo Chicken Zucchini Casserole

Enjoy tender chicken, zucchini, and creamy Alfredo sauce layered with cheese for a delicious baked family dish.

Prep duration
20 min
Cook duration
35 min
Complete duration
55 min
Created by Hannah Lewis


Skill level Easy

Heritage American-Italian

Output 4 Portions

Dietary guidelines Low-Carbohydrate

Components

Proteins

01 2 cups cooked chicken breast, cubed or shredded (about 2 medium chicken breasts)

Vegetables

01 3 medium zucchinis, sliced into 1/4-inch rounds
02 1 small onion, finely chopped
03 2 cloves garlic, minced

Sauce

01 1 1/2 cups Alfredo sauce (store-bought or homemade; gluten-free if needed)
02 1/2 cup sour cream

Cheese

01 1 cup shredded mozzarella cheese
02 1/2 cup grated Parmesan cheese

Seasonings

01 1/2 teaspoon dried Italian herbs
02 1/4 teaspoon salt
03 1/4 teaspoon black pepper

Optional Garnish

01 2 tablespoons chopped fresh parsley

Directions

Stage 01

Oven Preparation: Preheat oven to 375°F. Lightly grease a 9x13-inch casserole dish.

Stage 02

Sauté Aromatics: Heat a large skillet over medium and add a splash of olive oil. Sauté the chopped onion for 3 minutes until translucent, then add minced garlic and cook for 1 additional minute.

Stage 03

Cook Zucchini: Add zucchini slices to the skillet and cook for 5 minutes, stirring gently, just until tender but still holding shape. Remove skillet from heat.

Stage 04

Combine Ingredients: In a large mixing bowl, combine the cooked chicken, sautéed onion, garlic, zucchini, Alfredo sauce, sour cream, dried Italian herbs, salt, and black pepper. Mix gently until incorporated.

Stage 05

Assemble Casserole: Evenly spread the mixture into the prepared casserole dish. Sprinkle shredded mozzarella and grated Parmesan cheese on top.

Stage 06

Bake: Bake uncovered for 25 to 30 minutes until bubbling and the cheese is golden brown.

Stage 07

Finish and Serve: Let the casserole rest for 5 minutes after baking. Garnish with chopped fresh parsley and serve warm.

Necessary tools

  • 9x13-inch casserole dish
  • Large skillet
  • Mixing bowl
  • Chef’s knife
  • Cutting board
  • Wooden spoon or spatula

Allergy details

Review each component for potential allergens and consult with healthcare professionals if you're uncertain about ingredients.
  • Contains dairy from Alfredo sauce, sour cream, and cheeses.
  • Possible gluten content depending on Alfredo sauce selection.
  • Contains milk proteins.
  • Verify all packaged ingredients for hidden allergens.

Nutrient content (per portion)

These values are approximate guidelines only and shouldn't replace professional nutritional advice.
  • Energy: 410
  • Fats: 25 g
  • Carbohydrates: 10 g
  • Proteins: 36 g