Baked Pesto Chicken Mac & Cheese

Featured in: Dinner Grin

Layers of juicy pesto-marinated chicken pieces are folded into an ultra-creamy blend of sharp cheddar, mozzarella, and parmesan mac and cheese. The entire casserole gets topped with buttery panko crumbs mixed with extra parmesan and pesto, then baked until golden and bubbly. Ready in just one hour, this Italian-American comfort main serves six generously.

Updated on Sun, 08 Feb 2026 13:12:21 GMT
Golden brown panko topping covers Baked Pesto Chicken Mac & Cheese, with bubbly cheese peeking through. Save
Golden brown panko topping covers Baked Pesto Chicken Mac & Cheese, with bubbly cheese peeking through. | grinnosh.com

Discover the perfect fusion of Italian flair and classic American comfort with this Baked Pesto Chicken Mac & Cheese. This recipe transforms traditional macaroni and cheese into a sophisticated casserole by layering tender, pesto-marinated chicken and a velvety three-cheese sauce, all topped off with a satisfyingly crispy parmesan panko crust.

Golden brown panko topping covers Baked Pesto Chicken Mac & Cheese, with bubbly cheese peeking through. Save
Golden brown panko topping covers Baked Pesto Chicken Mac & Cheese, with bubbly cheese peeking through. | grinnosh.com

Whether you are looking for a satisfying weeknight meal or a hearty dish to serve at a gathering, this bubbly, golden casserole is sure to impress. The addition of nutmeg and garlic powder to the cheese sauce adds a depth of flavor that perfectly complements the herbaceous chicken.

Ingredients

  • Pasta: 400 g (14 oz) elbow macaroni or short pasta
  • Chicken & Marinade: 2 large boneless, skinless chicken breasts (about 400 g/14 oz), 3 tbsp basil pesto, 1 tbsp olive oil, 1/2 tsp salt, 1/4 tsp black pepper
  • Cheese Sauce: 3 tbsp unsalted butter, 3 tbsp all-purpose flour, 2 cups (480 ml) whole milk (warmed), 1 cup (240 ml) heavy cream, 2 cups (200 g) shredded sharp cheddar cheese, 1 cup (90 g) grated mozzarella cheese, 1/2 cup (50 g) grated parmesan cheese, 1/2 tsp garlic powder, 1/4 tsp ground nutmeg, salt and pepper, to taste
  • Topping: 1 cup (100 g) panko breadcrumbs, 2 tbsp melted butter, 1/4 cup (25 g) grated parmesan cheese, 2 tbsp basil pesto
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Instructions

Step 1
Preheat oven to 200°C (400°F). Grease a 23x33 cm (9x13-inch) baking dish.
Step 2
Cook the pasta in salted boiling water 2 minutes less than package instructions (it will finish in the oven). Drain and set aside.
Step 3
While pasta cooks, butterfly the chicken breasts and cut into bite-sized pieces. Toss with 3 tbsp pesto, olive oil, salt, and pepper. Let marinate 10 minutes.
Step 4
In a large skillet over medium-high heat, sear the chicken pieces until just cooked through, about 5–6 minutes. Remove from heat.
Step 5
For the cheese sauce, melt butter in a large saucepan over medium heat. Whisk in flour and cook 1 minute. Gradually whisk in milk and cream. Stir constantly until slightly thickened, about 3–4 minutes.
Step 6
Lower heat and stir in cheddar, mozzarella, and parmesan cheeses until melted and smooth. Add garlic powder, nutmeg, salt, and pepper. Remove from heat.
Step 7
Combine the cooked pasta, cheese sauce, and pesto chicken in a large bowl. Mix gently to combine.
Step 8
Pour mixture into prepared baking dish.
Step 9
In a small bowl, mix panko, melted butter, parmesan, and pesto for the topping. Sprinkle evenly over the casserole.
Step 10
Bake 20–25 minutes, until topping is golden and casserole is bubbling. Let rest 5–10 minutes before serving.

Zusatztipps für die Zubereitung

Using a whisk is essential for creating a smooth roux when making the cheese sauce. To save time and streamline your workflow, prepare the chicken marinade while the pasta water comes to a boil. Essential tools for this recipe include a large pot, a large skillet, a saucepan, and a 23x33 cm baking dish.

Varianten und Anpassungen

For a quicker preparation, you can substitute the chicken breasts with store-bought rotisserie chicken—simply toss it with pesto before folding it into the sauce. For a different flavor profile, try swapping the mozzarella for smoked gouda or fontina cheese to add a more complex, smoky note to the dish.

Serviervorschläge

This rich and creamy mac and cheese pairs beautifully with a crisp green salad to balance the flavors. For the perfect beverage pairing, enjoy a serving with a chilled glass of Sauvignon Blanc.

Close-up of Baked Pesto Chicken Mac & Cheese, featuring marinated chicken pieces and creamy macaroni. Save
Close-up of Baked Pesto Chicken Mac & Cheese, featuring marinated chicken pieces and creamy macaroni. | grinnosh.com

With its vibrant pesto aromatics and golden panko finish, this Baked Pesto Chicken Mac & Cheese is a guaranteed crowd-pleaser that brings a little Italian inspiration to the dinner table. Enjoy every cheesy, herb-filled bite!

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Recipe FAQ

Can I make this ahead of time?

Assemble everything up to 24 hours before baking. Cover tightly and refrigerate, then add 10-15 minutes to the baking time since it will be cold. Add the fresh topping just before baking for the crispiest results.

What pasta shapes work best?

Elbow macaroni, cavatappi, shells, or penne capture the creamy sauce beautifully. Short pasta with ridges or cups holds onto both the cheese sauce and pesto chicken pieces.

Can I use store-bought rotisserie chicken?

Absolutely. Shred about 3 cups of rotisserie chicken and toss with the pesto marinade. Skip the searing step and fold directly into the cheese sauce with the pasta.

How do I store leftovers?

Cool completely, then store in an airtight container for up to 4 days. Reheat individual portions in the microwave, or cover with foil and warm at 180°C (350°F) until heated through.

Can I freeze this casserole?

Yes, freeze before baking for up to 3 months. Wrap tightly in plastic and foil. Thaw overnight in the refrigerator, then bake with the topping added fresh. Already-baked portions freeze well for 2 months.

What cheeses work in the sauce blend?

Sharp cheddar provides tang, mozzarella creates the signature stretch, and parmesan adds nutty depth. Try swapping in fontina, gruyère, or smoked gouda for variations on the flavor profile.

Baked Pesto Chicken Mac & Cheese

Tender pesto chicken meets creamy three-cheese pasta with crispy parmesan topping

Prep duration
25 min
Cook duration
35 min
Complete duration
60 min
Created by Hannah Lewis


Skill level Medium

Heritage Italian-American

Output 6 Portions

Dietary guidelines None specified

Components

Pasta

01 14 oz elbow macaroni or short pasta

Chicken & Marinade

01 2 large boneless, skinless chicken breasts, approximately 14 oz total
02 3 tablespoons basil pesto
03 1 tablespoon extra virgin olive oil
04 1/2 teaspoon kosher salt
05 1/4 teaspoon freshly ground black pepper

Cheese Sauce

01 3 tablespoons unsalted butter
02 3 tablespoons all-purpose flour
03 2 cups whole milk, warmed
04 1 cup heavy cream
05 2 cups shredded sharp cheddar cheese
06 1 cup grated mozzarella cheese
07 1/2 cup grated parmesan cheese
08 1/2 teaspoon garlic powder
09 1/4 teaspoon ground nutmeg
10 Salt and freshly ground black pepper to taste

Topping

01 1 cup panko breadcrumbs
02 2 tablespoons unsalted butter, melted
03 1/4 cup grated parmesan cheese
04 2 tablespoons basil pesto

Directions

Stage 01

Prepare Baking Vessel: Preheat oven to 400°F. Lightly grease a 9x13-inch baking dish with butter or cooking spray.

Stage 02

Undercook Pasta: Cook pasta in generously salted boiling water for 2 minutes less than package directions to ensure it finishes properly during baking. Drain thoroughly and set aside.

Stage 03

Marinate Chicken: While pasta cooks, butterfly chicken breasts and cut into bite-sized pieces. Toss with basil pesto, olive oil, salt, and pepper. Allow to marinate for 10 minutes at room temperature.

Stage 04

Sear Chicken: Heat a large skillet over medium-high heat. Sear pesto-marinated chicken pieces until cooked through, approximately 5 to 6 minutes. Transfer to a clean plate.

Stage 05

Create Roux: In a large saucepan over medium heat, melt butter. Whisk in flour and cook, stirring constantly, for 1 minute until golden.

Stage 06

Build Cheese Sauce: Gradually whisk warmed milk and heavy cream into the roux, stirring constantly until the mixture thickens slightly, approximately 3 to 4 minutes. Reduce heat to low and add cheddar, mozzarella, and parmesan cheeses, stirring until completely melted and smooth. Season with garlic powder, nutmeg, salt, and pepper to taste.

Stage 07

Combine Components: In a large mixing bowl, gently combine the cooked pasta, cheese sauce, and pesto chicken until evenly distributed.

Stage 08

Transfer to Baking Dish: Pour the pasta mixture into the prepared baking dish, spreading evenly.

Stage 09

Prepare Topping: In a small bowl, combine panko breadcrumbs, melted butter, grated parmesan cheese, and basil pesto. Mix until breadcrumbs are evenly coated.

Stage 10

Add Topping and Bake: Sprinkle the panko mixture evenly over the casserole. Bake for 20 to 25 minutes until the topping becomes golden brown and the casserole bubbles at the edges.

Stage 11

Rest and Serve: Remove from oven and allow the casserole to rest for 5 to 10 minutes before serving. This resting period allows the sauce to set slightly for cleaner portions.

Necessary tools

  • Large pot for cooking pasta
  • Large skillet for searing chicken
  • Large saucepan for cheese sauce preparation
  • Whisk for sauce emulsification
  • 9x13-inch ceramic or glass baking dish
  • Multiple mixing bowls for ingredient organization

Allergy details

Review each component for potential allergens and consult with healthcare professionals if you're uncertain about ingredients.
  • Contains wheat gluten (in pasta and breadcrumbs)
  • Contains dairy products (butter, milk, cream, multiple cheeses)
  • May contain eggs (possible in some pasta varieties)
  • May contain tree nuts (present in basil pesto)
  • Contains poultry (chicken)

Nutrient content (per portion)

These values are approximate guidelines only and shouldn't replace professional nutritional advice.
  • Energy: 670
  • Fats: 36 g
  • Carbohydrates: 49 g
  • Proteins: 39 g