Baked Pesto Chicken Mac & Cheese

Featured in: Dinner Grin

This comforting baked casserole combines tender pesto-seasoned chicken with al dente macaroni enveloped in a rich three-cheese sauce featuring mozzarella, Parmesan, and sharp cheddar. The dish bakes until bubbling with a golden, crispy panko crust that adds satisfying crunch to every bite. Ready in under an hour, this American-Italian fusion main yields six generous servings and works beautifully for weeknight dinners or casual family gatherings.

Updated on Mon, 09 Feb 2026 15:24:02 GMT
Golden-brown Baked Pesto Chicken Mac & Cheese casserole fresh from the oven with bubbling cheese and herbs. Save
Golden-brown Baked Pesto Chicken Mac & Cheese casserole fresh from the oven with bubbling cheese and herbs. | grinnosh.com

Experience the ultimate fusion of comfort and flavor with this Baked Pesto Chicken Mac & Cheese. This dish transforms a childhood classic into a gourmet experience by combining tender chicken breast, aromatic basil pesto, and a decadent blend of mozzarella, cheddar, and Parmesan cheeses. It is a hearty, golden-brown masterpiece that delivers a savory satisfying crunch with every bite.

Golden-brown Baked Pesto Chicken Mac & Cheese casserole fresh from the oven with bubbling cheese and herbs. Save
Golden-brown Baked Pesto Chicken Mac & Cheese casserole fresh from the oven with bubbling cheese and herbs. | grinnosh.com

Whether you are hosting a family gathering or simply looking for a new weeknight staple, this casserole hits all the right notes. The preparation is straightforward, and the result is a sophisticated take on macaroni and cheese that will have everyone reaching for seconds.

Ingredients

  • Pasta: 400 g (14 oz) elbow macaroni
  • Chicken: 500 g (1.1 lb) boneless, skinless chicken breast (cut into bite-sized pieces), 2 tbsp olive oil, 1/2 tsp salt, 1/4 tsp black pepper, 1/2 tsp dried Italian herbs
  • Pesto: 100 g (1/2 cup) basil pesto (store-bought or homemade)
  • Sauce: 3 tbsp unsalted butter, 3 tbsp all-purpose flour, 700 ml (3 cups) whole milk, 150 g (1 1/2 cups) shredded mozzarella cheese, 100 g (1 cup) shredded Parmesan cheese, 100 g (1 cup) shredded sharp cheddar cheese, 1/2 tsp garlic powder, salt and pepper to taste
  • Topping: 40 g (1/2 cup) panko breadcrumbs, 30 g (1/4 cup) grated Parmesan cheese, 1 tbsp olive oil
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Instructions

Step 1
Preheat oven to 200°C (400°F). Grease a large baking dish (about 23x33 cm/9x13 in).
Step 2
Bring a large pot of salted water to a boil. Cook macaroni until al dente, drain, and set aside.
Step 3
While pasta cooks, heat 2 tbsp olive oil in a skillet over medium heat. Add chicken, season with salt, pepper, and Italian herbs. Cook until golden and cooked through, about 6–8 minutes. Remove from heat and toss with basil pesto.
Step 4
In a large saucepan, melt butter over medium heat. Whisk in flour and cook for 1 minute. Gradually whisk in milk, stirring constantly until thickened (about 4–5 minutes).
Step 5
Remove from heat and stir in mozzarella, Parmesan, cheddar, and garlic powder. Season with salt and pepper.
Step 6
Combine cooked macaroni, cheese sauce, and pesto chicken in a large bowl. Mix gently to coat.
Step 7
Spoon mixture into prepared baking dish.
Step 8
In a small bowl, combine panko, Parmesan, and olive oil. Sprinkle evenly over casserole.
Step 9
Bake for 20–25 minutes until bubbling and golden brown on top.
Step 10
Let rest 5 minutes before serving.

Zusatztipps für die Zubereitung

For an even quicker preparation on busy nights, you can substitute the cooked chicken breast with a pre-cooked rotisserie chicken shredded into bite-sized pieces.

Varianten und Anpassungen

To add more color and nutrients, try folding in sautéed spinach or chopped sun-dried tomatoes before baking. For a different flavor profile, you can swap the cheddar for smoked gouda or fontina cheese.

Serviervorschläge

This rich casserole pairs beautifully with a crisp, fresh green salad to balance the cheesiness. For a complete dining experience, serve it alongside a glass of chilled Sauvignon Blanc.

Creamy Baked Pesto Chicken Mac & Cheese served in a skillet with a side salad and wine. Save
Creamy Baked Pesto Chicken Mac & Cheese served in a skillet with a side salad and wine. | grinnosh.com

With approximately 620 calories and 36g of protein per serving, this meal is as nourishing as it is delicious. Please note that this dish contains gluten (pasta, flour, panko) and dairy (milk, cheese, butter). Enjoy your homemade Baked Pesto Chicken Mac & Cheese!

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Recipe FAQ

Can I prepare this casserole ahead of time?

Assemble the entire dish up to 24 hours in advance, cover tightly, and refrigerate. Add an extra 10-15 minutes to baking time since it will be cold. Alternatively, bake fully and reheat individual portions.

What type of pesto works best?

Traditional basil pesto with pine nuts delivers classic flavor, but you can use sun-dried tomato pesto for deeper color or make your own to control ingredients. If using store-bought, check for nut content if allergies are a concern.

Can I use different pasta shapes?

Elbow macaroni holds sauce beautifully, but cavatappi, penne, or shells work equally well. Choose shapes with nooks and crannies that trap the creamy cheese sauce and pesto-coated chicken pieces.

How do I prevent the topping from burning?

Watch closely during the last 5 minutes of baking. If the breadcrumbs brown too quickly, loosely tent with foil. The casserole is done when bubbling around edges and the topping reaches deep golden brown.

Can I freeze leftovers?

Portion cooled casserole into airtight containers and freeze up to 3 months. Thaw overnight in refrigerator, then reheat at 180°C (350°F) covered for 20 minutes, uncovering for the last 5-10 minutes to recrisp the topping.

What vegetables can I add?

Sautéed spinach, blanched broccoli florets, or roasted sun-dried tomatoes complement the pesto flavors without overpowering. Add about 2 cups vegetables when combining pasta with sauce and chicken.

Baked Pesto Chicken Mac & Cheese

Golden casserole with pesto chicken, creamy cheese sauce, and crispy breadcrumb topping

Prep duration
20 min
Cook duration
35 min
Complete duration
55 min
Created by Hannah Lewis


Skill level Medium

Heritage American-Italian

Output 6 Portions

Dietary guidelines None specified

Components

Pasta

01 14 oz elbow macaroni

Chicken

01 1.1 lb boneless, skinless chicken breast, cut into bite-sized pieces
02 2 tablespoons olive oil
03 1/2 teaspoon salt
04 1/4 teaspoon black pepper
05 1/2 teaspoon dried Italian herbs

Pesto

01 1/2 cup basil pesto, store-bought or homemade

Sauce

01 3 tablespoons unsalted butter
02 3 tablespoons all-purpose flour
03 3 cups whole milk
04 1.5 cups shredded mozzarella cheese
05 1 cup shredded Parmesan cheese
06 1 cup shredded sharp cheddar cheese
07 1/2 teaspoon garlic powder
08 Salt and pepper to taste

Topping

01 1/2 cup panko breadcrumbs
02 1/4 cup grated Parmesan cheese
03 1 tablespoon olive oil

Directions

Stage 01

Prepare the oven and baking dish: Preheat oven to 400°F. Grease a 9x13 inch baking dish with cooking spray or butter.

Stage 02

Cook the macaroni: Bring a large pot of salted water to a boil. Cook macaroni until al dente according to package directions, then drain and set aside.

Stage 03

Sear the chicken: While pasta cooks, heat 2 tablespoons olive oil in a skillet over medium heat. Add chicken pieces, season with salt, pepper, and Italian herbs. Cook until golden and cooked through, approximately 6 to 8 minutes. Remove from heat and toss with basil pesto.

Stage 04

Build the cheese sauce: In a large saucepan, melt butter over medium heat. Whisk in flour and cook for 1 minute. Gradually whisk in milk while stirring constantly until thickened, about 4 to 5 minutes. Remove from heat and stir in mozzarella, Parmesan, cheddar, and garlic powder. Season with salt and pepper to taste.

Stage 05

Combine all components: In a large bowl, gently combine cooked macaroni, cheese sauce, and pesto chicken, ensuring even coating throughout.

Stage 06

Transfer to baking dish: Spoon the mixture into the prepared baking dish and spread evenly.

Stage 07

Prepare the topping: In a small bowl, combine panko breadcrumbs, Parmesan cheese, and olive oil. Sprinkle evenly over the casserole.

Stage 08

Bake the casserole: Bake for 20 to 25 minutes until the casserole is bubbling and the top is golden brown.

Stage 09

Rest and serve: Remove from oven and allow to rest for 5 minutes before serving to allow the casserole to set.

Necessary tools

  • Large pot
  • Skillet
  • Large saucepan
  • Mixing bowls
  • Whisk
  • 9x13 inch baking dish
  • Measuring cups and spoons

Allergy details

Review each component for potential allergens and consult with healthcare professionals if you're uncertain about ingredients.
  • Contains gluten from pasta, all-purpose flour, and panko breadcrumbs
  • Contains dairy including milk, multiple cheese varieties, and butter
  • May contain tree nuts if basil pesto is prepared with pine nuts; verify store-bought pesto ingredient labels
  • Review all product labels carefully for cross-contamination warnings if serving individuals with severe allergies

Nutrient content (per portion)

These values are approximate guidelines only and shouldn't replace professional nutritional advice.
  • Energy: 620
  • Fats: 30 g
  • Carbohydrates: 52 g
  • Proteins: 36 g